Aldosterone
endogenous
“Al-Dough stir own”
bananas dispersing → decreased serum potassium
retention of whater and sodium
What it isEndogenous mineralocorticoid driving sodium retention and potassium excretion.
Why this oneTarget of spironolactone, eplerenone and finerenone; explains their hyperkalemia.
What limits itEscape from ACE-inhibitor suppression explains adding an MRA in heart failure rather than relying on RAAS blockade alone.
NO BOXED WARNINGS
Principal riskEndogenous or dietary; no boxed warning applies
Classes and tags
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Self-check
- How does aldosterone affect potassium handling?
Increases potassium excretion. - Name three drugs targeting aldosterone’s action.
Spironolactone, eplerenone and finerenone.