5-LOX inhibitor
5-lipoxygenase inhibitor
- ↓ synthesis of all leukotrienes
- Broader than receptor blockade — cuts LTB4 as well as cysteinyl leukotrienes
- Hepatotoxicity
Drugs with this mechanism (3)
- Mesalamine — Topically acting 5-ASA for ulcerative colitis; delivery system defines the product.
- Mesalamine DR — Delayed-release 5-ASA for ulcerative colitis; formulation governs colonic delivery.
- Zileuton — 5-lipoxygenase inhibitor that blocks leukotriene synthesis rather than a leukotriene receptor.
Self-check
- Which leukotriene is also reduced by 5-LOX inhibition beyond cysteinyl leukotrienes?
LTB4. - Which organ toxicity limits 5-LOX inhibition?
Hepatotoxicity.
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