5-LOX inhibitor
- Blocks leukotriene synthesis
- Hepatotoxicity
Drugs with this mechanism (3)
- Mesalamine — Topically acting 5-ASA for ulcerative colitis; delivery system defines the product.
- Mesalamine DR — Delayed-release 5-ASA for ulcerative colitis; formulation governs colonic delivery.
- Zileuton — 5-lipoxygenase inhibitor that blocks leukotriene synthesis rather than a leukotriene receptor.
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