D1 partial agonist
D1 dopamine receptor partial agonist
- Partial agonism aims to limit D1 overstimulation with levodopa; reduced dyskinesia not shown (10% vs 2% placebo)
- Peripheral D1 vasodilation → orthostatic hypotension
- Partial agonism aims to limit D1 overstimulation with levodopa; reduced dyskinesia not shown (10% vs 2% placebo)
- Peripheral D1 vasodilation → orthostatic hypotension
Drugs with this mechanism (1)
- Tavapadon — Once-daily D1/D5 partial agonist for Parkinson disease; it does not act through the D2/D3 receptors the older dopamine agonists target.
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