Prefrontal cortex – enhances signal-to-noise ratio
➔ improves attention and working memory
➔ stimulants act indirectly (↑ synaptic DA) ◇ “Don’t be the Distracted One”
Striatum – direct pathway
➔ facilitates movement → ↓ bradykinesia
➔ pulsatile D1 stimulation contributes to levodopa-induced dyskinesia ◇ sensitization of direct pathway neurons ◇ maladaptive plasticity in striatal circuits