D1 agonist
D1 dopamine receptor agonist
- Renal and mesenteric vasodilation → ↓ blood pressure, ↑ renal blood flow
- Renal vasculature – D1-mediated vasodilation + natriuresis
- If BBB-crossing:
- Enhances prefrontal signal-to-noise → attention and working memory
- stimulants act indirectly (↑ synaptic DA) ◇ “Don’t be the Distracted One”
- Facilitates movement through the striatal direct pathway
- facilitates movement → ↓ bradykinesia
- Pulsatile stimulation can promote dyskinesia
- pulsatile D1 stimulation contributes to levodopa-induced dyskinesia ◇ sensitization of direct pathway neurons ◇ maladaptive plasticity in striatal circuits
Drugs with this mechanism (3)
- Dopamine — Dose-sensitive endogenous catecholamine agonist used IV for selected shock and hypotension.
- Fenoldopam — IV D1 agonist for hypertensive emergencies; preserves renal flow.
- Rotigotine — Transdermal dopamine agonist for Parkinson and restless legs.
Self-check
- How does peripheral D1 agonism affect renal blood flow?
Increases it. - Which striatal pathway does central D1 agonism facilitate?
The direct pathway.
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