BTK inhibitor
Bruton tyrosine kinase inhibitor
- Interrupts B-cell receptor signaling
- Impairs B-cell survival/proliferation → treats B-cell malignancies
- ↓ mast-cell/basophil FcεRI signaling → ↓ urticaria
- Bleeding
- Atrial fibrillation
Drugs with this mechanism (5)
- Acalabrutinib — Second-generation covalent BTK inhibitor with less atrial fibrillation than ibrutinib.
- Ibrutinib — BTK inhibitor for B-cell cancers; bleeding and atrial fibrillation.
- Pirtobrutinib — Noncovalent BTK inhibitor that remains active after many covalent BTK inhibitors fail.
- Remibrutinib — Oral BTK inhibitor for antihistamine-refractory chronic spontaneous urticaria and symptomatic dermographism.
- Zanubrutinib — More selective covalent BTK inhibitor for CLL, mantle cell lymphoma, and Waldenstrom macroglobulinemia.
Self-check
- Which immune-cell signaling pathway does BTK inhibition interrupt?
B-cell receptor signaling. - What arrhythmia is associated with BTK inhibition?
Atrial fibrillation.
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