Beta-1 agonist
Beta-1 adrenergic receptor agonist
- Cardiac: ↑ heart rate, contractility and AV conduction
- opposing parasympathetic effects of M2 agonists
- Inotropic support in acute heart failure and shock
- Excess stimulation → arrhythmia and ↑ myocardial oxygen demand
- Renin release→ ↑ BP
- CNS effects (via NE, not Epi)
- ↑ alertness, ↑ arousal, mild anxiety or jitteriness
Drugs with this mechanism (5)
- Dobutamine — Beta-1 inotrope; titratable within minutes.
- Dopamine — Dose-sensitive endogenous catecholamine agonist used IV for selected shock and hypotension.
- Epinephrine — Endogenous catecholamine; the first-line drug for anaphylaxis and arrest.
- Isoproterenol — Nonselective beta agonist; increases heart rate and contractility.
- Norepinephrine — Endogenous catecholamine; the first-line vasopressor for shock.
Self-check
- What oxygen-demand change accompanies excessive beta-1 stimulation?
Increased myocardial oxygen demand. - Which renal hormone is released with beta-1 activation?
Renin.
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