5-HT4 agonist

5-HT4 serotonin receptor agonist

↑ GI motility and intestinal transit
Possible pro-cognitive effect (early human studies)

Drugs with this mechanism (3)

Cisapride — 5-HT4 prokinetic withdrawn for fatal QT arrhythmias.
Prucalopride — Selective 5-HT4 agonist prokinetic for chronic constipation.
Serotonin — Endogenous monoamine neurotransmitter (5-HT).

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