5-HT2B antagonist

Name: 5-HT2B antagonist
Creator: Jason Cafer, MD

5-HT2B serotonin receptor antagonist

Drugs with this mechanism (7)

Aripiprazole — D2 partial agonist; weight-favorable, activating, low prolactin; can cause akathisia.
Aripiprazole lauroxil LAI — Long-acting aripiprazole prodrug injection for schizophrenia; requires a loading strategy.
Aripiprazole lauroxil LAI — Rapid-start aripiprazole lauroxil injection used only to initiate Aristada treatment.
Aripiprazole monohydrate LAI — Extended-interval aripiprazole LAI for schizophrenia and bipolar maintenance.
Aripiprazole monohydrate LAI — Long-acting aripiprazole for schizophrenia and bipolar maintenance; akathisia remains prominent.
Desmethyl cariprazine — Cariprazine metabolite with the same D3-preferring partial agonism as the parent.
Didesmethyl cariprazine — Cariprazine's long-lived second metabolite — the reason steady state takes weeks and washout takes longer.