Prostaglandin E₂
endogenous
What it isCyclooxygenase product acting at the EP1–EP4 receptors; gastric mucus and bicarbonate, uterine tone, fever, pain sensitization.
Why this oneRemoving it is what NSAIDs do, and replacing it is what misoprostol does — one mediator explains both the ulcer and its prevention.
What limits itAs dinoprostone it ripens the cervix; its fever role is why COX inhibition is antipyretic.
NO BOXED WARNINGS
Classes and tags
Clinical profile
Defining liabilityUterine tachysystole with fetal distress and possible uterine rupture