Motilin

What it isDuodenal peptide that initiates phase III of the migrating motor complex between meals.

Why this oneErythromycin is a motilin receptor agonist, which is why a macrolide antibiotic is used for gastroparesis and to clear the stomach before endoscopy.

What limits itTachyphylaxis within days limits erythromycin's prokinetic use; no selective motilin agonist is marketed.