Loxapine inhaled
ADASUVE
Pronunciation: LOX-a-peen
“Lotsa ping, Lotsa Tang”
Spooky mascot → antipsychotic
What it isInhaled loxapine (ADASUVE) for acute agitation in schizophrenia or bipolar I disorder: one 10 mg breath from a single-use inhaler; no second dose within 24 h.
Why this onePeak plasma level in about 2 minutes — IV-like speed without a needle; half-life 6–8 h.
What limits itBoxed warning: bronchospasm (plus dementia-related mortality). REMS-certified settings only, with a short-acting bronchodilator at hand; contraindicated in asthma, COPD or any bronchospastic lung disease.
FDA-approved for
- acute agitation in schizophrenia or bipolar I disorder (2012)
⚠ BOXED WARNINGS
- Bronchospasm
- Increased mortality in elderly patients with dementia-related psychosis
Classes and tags
Clinical profile
Legacy pregnancy categoryC
Defining liabilityMetabolic effects, extrapyramidal symptoms/tardive dyskinesia and agent-specific QT or orthostatic risk.
Active metabolites
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