Zolpidem SL middle-of-night
INTERMEZZO
What it isSublingual GABA-A positive allosteric modulator in 1.75/3.5 mg strengths; insomnia marked by middle-of-the-night awakening.
Why this oneIt is the only insomnia label for middle-of-the-night awakening, targeting a single late-night awakening rather than bedtime sleep initiation.
What limits itTake only with ≥4 h of bed time remaining; women dose 1.75 mg (slower zolpidem clearance). Next-morning impairment and complex sleep behaviors can cause serious injury.
FDA-approved for
- insomnia — middle-of-the-night awakening (2011)
⚠ BOXED WARNING
- Complex sleep behaviors including sleepwalking and sleep-driving
Classes and tags
Clinical profile
Mechanism of action: Zolpidem SL middle-of-night ballicule
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Open Zolpidem SL middle-of-night in the interactive console ↗