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Halazepam

PAXIPAM

Halazepam ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Halazepam ballicule

What it isDiscontinued benzodiazepine anxiolytic whose activity came largely from conversion to the long-acting metabolite nordiazepam.

Why this oneIt offered nothing its relatives did not, and was withdrawn from the market as a business decision rather than for safety.

What limits itIts main teaching value is as another spoke of the nordiazepam family wheel.

Halazepam molecular structure (skeletal formula)
Molecular structure: Halazepam

Halazepam prescription history

Animated chart of estimated U.S. prescriptions per year, Benzodiazepines (1961–2026). Halazepam enters in 1981 (estimated).

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Classes and tags

Clinical profile

Therapeutic safety burden3 / 4
Sedation liability2 / 4
Direct muscarinic antagonism0 / 4

Defining liabilitySedation, ataxia and long-lived active metabolite accumulation

Active metabolites

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