GLP-1 (7-36)
endogenous
What it isIncretin released by intestinal L cells after a meal; glucose-dependent insulin release, slowed gastric emptying, central satiety.
Why this oneDPP-4 cleaves it within about two minutes, which is the whole reason the drug class exists in two forms — DPP-4 inhibitors protect the native peptide, GLP-1 agonists replace it with a resistant one.
What limits itBeing glucose-dependent, the native hormone does not by itself cause hypoglycemia.
NO BOXED WARNINGS