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Glipizide ER

GLUCOTROL XL

What it isSulfonylurea that closes beta-cell KATP channels to release insulin; type 2 diabetes.

Why this oneIts shorter hypoglycemic tail than glyburide makes it a preferred sulfonylurea when kidney function is reduced.

What limits itMissed meals can provoke hypoglycemia; weight gain and progressive beta-cell failure limit durability.

NO BOXED WARNINGS

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Glipizide ER ballicule

Glipizide ER ballicule: receptor binding, kinetics and half-life diagram

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