GIP
endogenous
What it isThe other incretin, from duodenal K cells; like GLP-1 it is glucose-dependent and DPP-4-cleaved.
Why this oneIt is the half of tirzepatide that is not GLP-1 — the reason a dual agonist outperforms a GLP-1 agonist alone.
What limits itIn type 2 diabetes the insulinotropic response to GIP is blunted, which is why GIP alone was never a drug.
NO BOXED WARNINGS