UGT2B7 substrate
- Cleared substantially by UGT2B7 glucuronidation
- UGT2B7 inhibitors can raise exposure
- UGT2B7 inducers can lower exposure
- Effect depends on contribution of other pathways
- Conjugation DDIs can be large for sensitive drugs
Interaction at a glance
- Cleared substantially by UGT2B7 glucuronidation
Magnitude / time course
- Cleared substantially by UGT2B7 glucuronidation
- UGT2B7 inhibitors can raise exposure
Exposure modifiers
- UGT2B7 inducers can lower exposure
- Conjugation DDIs can be large for sensitive drugs
Mechanism
- Effect depends on contribution of other pathways
Self-check
- Which pathway substantially clears drugs tagged as UGT2B7 substrate?
UGT2B7 glucuronidation.
Drugs in this interaction (7)
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