UGT1A1 substrate
- Cleared substantially by UGT1A1 glucuronidation
- UGT1A1 inhibitors can raise exposure
- UGT1A1 inducers can lower exposure
- Effect depends on contribution of other pathways
- Conjugation DDIs can be large for sensitive drugs
Interaction at a glance
- Cleared substantially by UGT1A1 glucuronidation
Magnitude / time course
- Cleared substantially by UGT1A1 glucuronidation
- UGT1A1 inhibitors can raise exposure
Exposure modifiers
- UGT1A1 inducers can lower exposure
- Conjugation DDIs can be large for sensitive drugs
Mechanism
- Effect depends on contribution of other pathways
Self-check
- What can limit a UGT1A1-substrate interaction’s magnitude?
Contribution of other clearance pathways. - What can UGT1A1 inhibition do to substrate exposure?
Raise it.
Drugs in this interaction (7)
All interaction examples · Open UGT1A1 substrate in the interactive console ↗