Renal clearance (tubular competition)
- Drugs compete for renal tubular transport
- One drug can reduce secretion of another
- Plasma exposure may rise despite unchanged GFR
- OAT/OCT/MATE pathways are common sites
- Classic examples include methotrexate/lithium DDIs
Interaction at a glance
- Drugs compete for renal tubular transport
Mechanism
- Drugs compete for renal tubular transport
- OAT/OCT/MATE pathways are common sites
- Classic examples include methotrexate/lithium DDIs
Magnitude / time course
- Plasma exposure may rise despite unchanged GFR
Management
- One drug can reduce secretion of another
Self-check
- Which transport pathways commonly mediate tubular competition?
OAT, OCT and MATE. - Can tubular competition raise exposure despite unchanged GFR?
Yes.
Drugs in this interaction (11)
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