P-gp inhibitor
- Inhibits P-gp
- P-glycoprotein
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits P-gp
- P-glycoprotein
Mechanism
- Inhibits P-gp
- P-glycoprotein
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What determines a P-gp inhibitor’s exposure-effect direction?
Uptake versus efflux location. - For which drugs can P-gp interactions be clinically important?
Selected narrow-index drugs.
Drugs in this interaction (11)
All interaction examples · Open P-gp inhibitor in the interactive console ↗