P-gp inhibitor
- Inhibits P-gp
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
Mechanism
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What usually happens to a sensitive P-gp substrate when a P-gp inhibitor is added?
Its exposure increases.
Drugs in this interaction (11)
All interaction examples · Open the interactive console ↗
