P-gp inducer
- Induces P-gp transport activity/expression
- Substrate exposure often falls for efflux transporters
- Onset/offset develops over days
- Induction often accompanies CYP induction
- Clinical importance is substrate-specific
Interaction at a glance
- Induces P-gp transport activity/expression
Magnitude / time course
- Induces P-gp transport activity/expression
- Substrate exposure often falls for efflux transporters
Mechanism
- Onset/offset develops over days
Mechanism / modifiers
- Induction often accompanies CYP induction
- Clinical importance is substrate-specific
Self-check
- How does P-gp induction affect sensitive-substrate exposure?
It may fall. - How long does P-gp induction onset/offset develop over?
Days.
Drugs in this interaction (6)
All interaction examples · Open P-gp inducer in the interactive console ↗