P-gp inducer
- Induces P-gp transport activity/expression
- Substrate exposure often falls for efflux transporters
- Onset/offset develops over days
- Induction often accompanies CYP induction
- Clinical importance is substrate-specific
Interaction at a glance
- Induces P-gp transport activity/expression
Magnitude / time course
- Induces P-gp transport activity/expression
- Substrate exposure often falls for efflux transporters
Mechanism
- Onset/offset develops over days
Mechanism / modifiers
- Induction often accompanies CYP induction
- Clinical importance is substrate-specific
Self-check
- What usually happens to a sensitive P-gp substrate when a P-gp inducer is added?
Its exposure decreases.
Drugs in this interaction (6)
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