OCT2 inhibitor
- Inhibits OCT2
- OCT2 renal organic-cation transporter
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits OCT2
- OCT2 renal organic-cation transporter
Mechanism
- Inhibits OCT2
- OCT2 renal organic-cation transporter
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What usually happens to a sensitive OCT2 substrate when a OCT2 inhibitor is added?
Its exposure increases.
Drugs in this interaction (7)
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