OCT2 inhibitor
- Inhibits OCT2
- OCT2 renal organic-cation transporter
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits OCT2
- OCT2 renal organic-cation transporter
Mechanism
- Inhibits OCT2
- OCT2 renal organic-cation transporter
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What determines an OCT2 inhibitor’s exposure-effect direction?
Uptake versus efflux location. - What transport role and location characterize OCT2?
Renal organic-cation transporter.
Drugs in this interaction (7)
All interaction examples · Open OCT2 inhibitor in the interactive console ↗