OAT3 substrate
- Substrate of OAT3
- OAT3 renal organic-anion transporter
- Transporter changes can alter exposure/distribution
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Interaction at a glance
- Substrate of OAT3
- OAT3 renal organic-anion transporter
Mechanism
- Substrate of OAT3
- OAT3 renal organic-anion transporter
Magnitude / time course
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Exposure modifiers
- Transporter changes can alter exposure/distribution
Self-check
- What does “OAT3 substrate” mean?
Substrate of OAT3.
Drugs in this interaction (9)
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