NAT2 substrate
- Acetylated by N-acetyltransferase 2
- NAT2 slow/rapid acetylator phenotype alters exposure
- Isoniazid is the classic example
- Slow acetylation can raise toxicity risk
- Fast acetylation can lower exposure
Interaction at a glance
- Acetylated by N-acetyltransferase 2
Mechanism
- Acetylated by N-acetyltransferase 2
- Isoniazid is the classic example
Magnitude / time course
- NAT2 slow/rapid acetylator phenotype alters exposure
Clinical consequence
- Slow acetylation can raise toxicity risk
Exposure modifiers
- Fast acetylation can lower exposure
Self-check
- Key risk with NAT2 substrate?
Slow acetylation can raise toxicity risk. - Which drug is the classic NAT2 example?
Isoniazid.
Drugs in this interaction (7)
All interaction examples · Open NAT2 substrate in the interactive console ↗