MATE1 inhibitor
- Inhibits MATE1
- MATE1 renal/hepatic exporter
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits MATE1
- MATE1 renal/hepatic exporter
Mechanism
- Inhibits MATE1
- MATE1 renal/hepatic exporter
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What usually happens to a sensitive MATE1 substrate when a MATE1 inhibitor is added?
Its exposure increases.
Drugs in this interaction (8)
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