Grapefruit interaction
- Grapefruit inhibits intestinal CYP3A
- Oral CYP3A substrates can show higher exposure
- Effect can persist after the juice is gone
- Furanocoumarins—not acidity—drive interaction
- Magnitude depends on intestinal first-pass dependence
Interaction at a glance
- Grapefruit inhibits intestinal CYP3A
Magnitude / time course
- Grapefruit inhibits intestinal CYP3A
- Oral CYP3A substrates can show higher exposure
Mechanism
- Effect can persist after the juice is gone
- Furanocoumarins—not acidity—drive interaction
Mechanism / modifiers
- Magnitude depends on intestinal first-pass dependence
Self-check
- What major clinical effect is associated with Grapefruit interaction?
Magnitude depends on intestinal first-pass dependence.
Drugs in this interaction (17)
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