Distribution (fat sequestration)
- Lipophilic drug partitions into adipose tissue
- Apparent Vd and terminal half-life can increase
- Obesity may alter distribution/recovery
- Tissue release can prolong effects
- Plasma level may fall before body burden does
Interaction at a glance
- Lipophilic drug partitions into adipose tissue
Mechanism
- Lipophilic drug partitions into adipose tissue
Mechanism / modifiers
- Obesity may alter distribution/recovery
- Tissue release can prolong effects
Magnitude / time course
- Apparent Vd and terminal half-life can increase
- Plasma level may fall before body burden does
Self-check
- What does “Distribution (fat sequestration)” mean?
Lipophilic drug partitions into adipose tissue. - Can plasma levels fall before total body burden in fat sequestration?
Yes.
Drugs in this interaction (7)
All interaction examples · Open Distribution (fat sequestration) in the interactive console ↗