Digoxin + P-gp inhibitor
- Digoxin = classic P-gp victim
- P-gp inhibitors reduce efflux/clearance
- quinidine AUC ↑ ~55–80%
- serum digoxin may nearly double
- Verapamil/amiodarone also raise levels
- Check level; often reduce digoxin dose
Interaction at a glance
- P-gp inhibitors reduce efflux/clearance
- quinidine AUC ↑ ~55–80%
- serum digoxin may nearly double
- Check level; often reduce digoxin dose
Management
- Digoxin = classic P-gp victim
- P-gp inhibitors reduce efflux/clearance
- quinidine AUC ↑ ~55–80%
- serum digoxin may nearly double
Mechanism
- Verapamil/amiodarone also raise levels
Monitoring
- Check level; often reduce digoxin dose
Self-check
- What should be monitored with Digoxin + P-gp inhibitor?
level; often reduce digoxin dose.
- In Digoxin + P-gp inhibitor, what is the approximate magnitude of the exposure change?
quinidine AUC ↑ ~55–80%
- Which enzyme or transporter is central to the Digoxin + P-gp inhibitor interaction?
P-gp.
Drugs in this interaction (10)
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