Digoxin + P-gp inhibitor
- Digoxin = classic P-gp victim
- P-gp inhibitors reduce efflux/clearance
- quinidine AUC ↑ ~55–80%
- serum digoxin may nearly double
- Verapamil/amiodarone also raise levels
- Check level; often reduce digoxin dose
Interaction at a glance
- P-gp inhibitors reduce efflux/clearance
- quinidine AUC ↑ ~55–80%
- serum digoxin may nearly double
- Check level; often reduce digoxin dose
Management
- Digoxin = classic P-gp victim
- P-gp inhibitors reduce efflux/clearance
- quinidine AUC ↑ ~55–80%
- serum digoxin may nearly double
Mechanism
- Verapamil/amiodarone also raise levels
Monitoring
- Check level; often reduce digoxin dose
Self-check
- What should be monitored with Digoxin + P-gp inhibitor?
Level; often reduce digoxin dose. - Which other drugs can raise digoxin levels?
Verapamil and amiodarone. - How do P-gp inhibitors affect digoxin handling?
They reduce efflux/clearance.
Drugs in this interaction (10)
All interaction examples · Open Digoxin + P-gp inhibitor in the interactive console ↗