CYP2E1 substrate
- Cleared substantially by CYP2E1
- CYP2E1 inhibitors can raise exposure
- CYP2E1 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Alcohol and small toxicants are key contexts.
Interaction at a glance
- Cleared substantially by CYP2E1
Magnitude / time course
- Cleared substantially by CYP2E1
- CYP2E1 inhibitors can raise exposure
Exposure modifiers
- CYP2E1 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
Mechanism
- Alcohol and small toxicants are key contexts.
Self-check
- Which pathway substantially clears drugs tagged as CYP2E1 substrate?
CYP2E1.
Drugs in this interaction (6)
All interaction examples · Open the interactive console ↗
