CYP2C19 inhibitor
- Inhibits CYP2C19
- CYP2C19 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Toxicity risk rises with narrow-index victims
- Inhibition often begins faster than induction
- Genotype strongly affects several substrates.
Interaction at a glance
- Inhibits CYP2C19
Magnitude / time course
- Inhibits CYP2C19
- CYP2C19 substrate exposure can rise
Mechanism
- Effect is greatest for sensitive substrates
- Inhibition often begins faster than induction
- Genotype strongly affects several substrates.
Clinical consequence
- Toxicity risk rises with narrow-index victims
Self-check
- Key risk with CYP2C19 inhibitor?
Toxicity risk rises with narrow-index victims. - How does the onset of CYP2C19 inhibition often compare with induction?
Inhibition often begins faster.
Drugs in this interaction (13)
All interaction examples · Open CYP2C19 inhibitor in the interactive console ↗