CYP2C19 inducer
- Induces CYP2C19 activity/expression
- CYP2C19 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Genotype strongly affects several substrates.
Interaction at a glance
- Induces CYP2C19 activity/expression
Mechanism
- Induces CYP2C19 activity/expression
- CYP2C19 substrates usually clear faster
Mechanism / modifiers
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Genotype strongly affects several substrates.
Clinical consequence
- AUC/effect may fall → treatment failure
Self-check
- How long does CYP2C19 induction onset/offset usually take?
Over days. - How does CYP2C19 induction affect sensitive-substrate exposure?
It may fall.
Drugs in this interaction (8)
All interaction examples · Open CYP2C19 inducer in the interactive console ↗