CYP2C19 inducer
- Induces CYP2C19 activity/expression
- CYP2C19 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Genotype strongly affects several substrates.
Interaction at a glance
- Induces CYP2C19 activity/expression
Mechanism
- Induces CYP2C19 activity/expression
- CYP2C19 substrates usually clear faster
Mechanism / modifiers
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Genotype strongly affects several substrates.
Clinical consequence
- AUC/effect may fall → treatment failure
Self-check
- Which enzyme or transporter is central to the CYP2C19 inducer interaction?
CYP2C19.
- What usually happens to a sensitive CYP2C19 substrate when a CYP2C19 inducer is added?
Its exposure decreases.
Drugs in this interaction (8)
All interaction examples · Open the interactive console ↗
