CYP metabolism (autoinduction)
- Drug induces enzymes that clear itself
- Clearance rises during continued treatment
- Half-life/exposure can fall over days to weeks
- Dose needs may change after initiation
- Carbamazepine is the classic example
Interaction at a glance
- Drug induces enzymes that clear itself
Mechanism
- Drug induces enzymes that clear itself
- Carbamazepine is the classic example
Magnitude / time course
- Clearance rises during continued treatment
- Half-life/exposure can fall over days to weeks
Management
- Dose needs may change after initiation
Self-check
- What does “CYP metabolism (autoinduction)” indicate?
Clearance rises during continued treatment. - Which drug is the classic autoinduction example?
Carbamazepine.
Drugs in this interaction (4)
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