CYP inhibition (time-dependent)
- Inhibition strengthens with preincubation/time
- Often reflects reactive metabolite formation
- Interaction may build over repeated dosing
- Recovery can lag behind drug disappearance
- Mechanism-based inhibition is a subset
Interaction at a glance
- Inhibition strengthens with preincubation/time
Mechanism
- Inhibition strengthens with preincubation/time
- Often reflects reactive metabolite formation
Mechanism / modifiers
- Interaction may build over repeated dosing
Mechanism / exceptions
- Recovery can lag behind drug disappearance
- Mechanism-based inhibition is a subset
Self-check
- What does “CYP inhibition (time-dependent)” mean?
Inhibition strengthens with preincubation/time.
Drugs in this interaction (8)
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