CYP inhibition (mechanism-based)
- Inhibitor is metabolized into enzyme-inactivator
- Enzyme activity falls until new enzyme is made
- Effect can outlast plasma inhibitor concentration
- Onset may increase with repeated dosing
- Often called irreversible/mechanism-based inhibition
Interaction at a glance
- Inhibitor is metabolized into enzyme-inactivator
Mechanism
- Inhibitor is metabolized into enzyme-inactivator
- Enzyme activity falls until new enzyme is made
Mechanism / modifiers
- Effect can outlast plasma inhibitor concentration
Mechanism / exceptions
- Onset may increase with repeated dosing
- Often called irreversible/mechanism-based inhibition
Self-check
- What does “CYP inhibition (mechanism-based)” indicate?
Inhibitor is metabolized into enzyme-inactivator.
Drugs in this interaction (6)
All interaction examples · Open the interactive console ↗
