BBB: P-gp substrate
- P-gp pumps drug out of the brain
- CNS exposure can be lower than plasma suggests
- P-gp inhibition may increase brain entry
- Effect depends on other BBB transporters
- This tag is BBB-specific—not gut P-gp alone
Interaction at a glance
- P-gp pumps drug out of the brain
Mechanism
- P-gp pumps drug out of the brain
- P-gp inhibition may increase brain entry
Mechanism / modifiers
- Effect depends on other BBB transporters
- This tag is BBB-specific—not gut P-gp alone
Magnitude / time course
- CNS exposure can be lower than plasma suggests
Self-check
- What does P-gp do to brain exposure of its substrates?
It lowers brain exposure by efflux.
Drugs in this interaction (8)
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