Absorption (chelation)
- Drug forms a poorly absorbed metal complex
- Ca/Mg/Al/Fe are common partners
- Fluoroquinolones/tetracyclines are classics
- Exposure can fall enough to cause treatment failure
- Prevention = drug-specific dose separation
Interaction at a glance
- Drug forms a poorly absorbed metal complex
Mechanism
- Drug forms a poorly absorbed metal complex
Mechanism / modifiers
- Ca/Mg/Al/Fe are common partners
- Fluoroquinolones/tetracyclines are classics
Clinical consequence
- Exposure can fall enough to cause treatment failure
- Prevention = drug-specific dose separation
Self-check
- How does chelation affect absorption?
Drug forms a poorly absorbed metal complex. - Which antibiotic classes are classic chelation victims?
Fluoroquinolones and tetracyclines.
Drugs in this interaction (16)
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