Absorption (adsorption/binding ↓)
- Another product binds/adsorbs drug in the gut
- Free drug available for absorption falls
- Common with resins, charcoal + some fibers
- Separate administration when evidence supports it
- Severe binding can make the oral dose ineffective
Interaction at a glance
- Another product binds/adsorbs drug in the gut
Mechanism
- Another product binds/adsorbs drug in the gut
Mechanism / modifiers
- Free drug available for absorption falls
- Common with resins, charcoal + some fibers
Timing / washout
- Separate administration when evidence supports it
- Severe binding can make the oral dose ineffective
Self-check
- When should doses be separated for an adsorption/binding interaction?
When evidence supports it. - What can severe gut binding do to an oral dose?
Make it ineffective.
Drugs in this interaction (10)
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