Opioid antagonists
- Block opioid receptors
- Central agents reverse overdose or treat OUD/AUD
- Peripheral agents treat opioid constipation
- Naloxone is rapid emergency reversal
- Naltrexone is longer-acting
- Can precipitate withdrawal in opioid dependence
Class at a glance
Clinical role
- Central agents reverse overdose or treat OUD/AUD
- Peripheral agents treat opioid constipation
Members / distinctions
- Naloxone is rapid emergency reversal
- Naltrexone is longer-acting
Practical pearls
- Can precipitate withdrawal in opioid dependence
Self-check
- What is the main pharmacologic action of Opioid antagonists?
Block opioid receptors.
Drugs in this class (8)
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