MAO inhibitors (MAOIs)
- Inhibit monoamine oxidase A and/or B
- Nonselective MAO-A blockade is antidepressant
- MAO-B-selective drugs mainly treat Parkinson disease
- Potent SRIs/releasers can cause fatal ST
- Tyramine risk depends on degree of MAO-A blockade
- Washouts and interaction knowledge are essential
Class at a glance
- Inhibit monoamine oxidase A and/or B
Pharmacology
- Nonselective MAO-A blockade is antidepressant
Clinical role
- MAO-B-selective drugs mainly treat Parkinson disease
- Potent SRIs/releasers can cause fatal ST
- Washouts and interaction knowledge are essential
Safety / monitoring
- Tyramine risk depends on degree of MAO-A blockade
Self-check
- What do MAO-B-selective drugs mainly treat?
Parkinson disease. - What determines tyramine risk with MAO inhibitors?
The degree of MAO-A blockade.
Drugs in this class (11)
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