Macrolides
- 50S protein-synthesis inhibitors
- Atypical respiratory pathogens are a niche
- Azithromycin has few CYP interactions
- Clarithro/erythro strongly inhibit CYP3A
- GI effects + QT prolongation are common issues
- Resistance limits routine empiric use
- Azithro also has selected anti-inflammatory uses
Class at a glance
- 50S protein-synthesis inhibitors
Pharmacology
- Azithromycin has few CYP interactions
- Clarithro/erythro strongly inhibit CYP3A
Safety / monitoring
- Atypical respiratory pathogens are a niche
- GI effects + QT prolongation are common issues
Clinical role
- Resistance limits routine empiric use
- Azithro also has selected anti-inflammatory uses
Self-check
- Which macrolide has relatively few CYP interactions?
Azithromycin.
- Which macrolides strongly inhibit CYP3A?
Clarithromycin and erythromycin.
Drugs in this class (3)
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