Immunosuppressants

Class at a glance

• Suppress immune function to prevent/treat disease

Clinical role

• Uses: transplantation + autoimmunity

Pharmacology

• Mechanisms span CNI, mTOR, antimetabolite + steroid

Practical pearls

• Vaccination/screening should precede therapy

Safety / monitoring

• Infection and malignancy risk rise
• Organ toxicity differs by subclass

Self-check

• What are the main clinical uses of Immunosuppressants?
  Transplantation + autoimmunity.
• When should vaccination/screening occur for immunosuppressive therapy?
  Before therapy.

Drugs in this class (27)

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