Immunosuppressants (mTOR inhibitors)
- Sirolimus/everolimus inhibit mTOR
- Suppress lymphocyte proliferation
- Used in transplantation + selected cancers
- Hyperlipidemia + cytopenias are common
- Impair wound healing
- CYP3A/P-gp interactions are important
Class at a glance
- Sirolimus/everolimus inhibit mTOR
Pharmacology
- CYP3A/P-gp interactions are important
Clinical role
- Suppress lymphocyte proliferation
- Used in transplantation + selected cancers
Members / distinctions
- Hyperlipidemia + cytopenias are common
- Impair wound healing
Self-check
- How do mTOR inhibitors affect wound healing?
They impair it. - What common adverse effects occur with mTOR inhibitors?
Hyperlipidemia and cytopenias.
Drugs in this class (3)
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