Endogenous neurotransmitters (amino-acid)
- Fast synaptic transmitters built from amino acids
- Glutamate = major excitatory transmitter
- GABA = major inhibitory transmitter
- Glycine inhibits mainly spinal/brainstem circuits
- Receptor subtype determines drug effects
- Imbalance can alter seizure/excitotoxicity risk
Class at a glance
- Fast synaptic transmitters built from amino acids
Pharmacology
- GABA = major inhibitory transmitter
- Glycine inhibits mainly spinal/brainstem circuits
- Receptor subtype determines drug effects
Practical pearls
- Glutamate = major excitatory transmitter
Safety / monitoring
- Imbalance can alter seizure/excitotoxicity risk
Self-check
- What is the major excitatory amino-acid neurotransmitter?
Glutamate.
- What is the major inhibitory amino-acid neurotransmitter?
GABA.
Drugs in this class (4)
All drug classes · Open the interactive console ↗
