Diuretics (thiazide / thiazide-like)
- Mild–moderate distal-tubule natriuresis
- First-line hypertension drugs
- Chlorthalidone/indapamide are long acting
- HypoNa, hypoK, gout + glucose effects
- Reduce urinary calcium
- Useful for recurrent calcium stones
- Classic drug class that raises lithium
Class at a glance
- Mild–moderate distal-tubule natriuresis
Clinical role
- First-line hypertension drugs
Practical pearls
- Chlorthalidone/indapamide are long acting
- HypoNa, hypoK, gout + glucose effects
Other clinical roles
- Reduce urinary calcium
- Useful for recurrent calcium stones
- Classic drug class that raises lithium
Self-check
- Which drug class is first-line for hypertension?
Diuretics (thiazide / thiazide-like). - When are Diuretics (thiazide / thiazide-like) especially useful?
Recurrent calcium stones.
Drugs in this class (5)
Diuretics (thiazide / thiazide-like) prescription history
Animated chart of estimated U.S. prescriptions per year, Diuretics (1953–2026). Thiazide family highlighted from 1958.
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