Dissociatives
- Produce dissociation via NMDA blockade
- Ketamine is the clinical prototype
- Analgesic/anesthetic effects at higher exposure
- Rapid antidepressant effect at subanesthetic dose
- BP, perceptual + cognitive effects are common
- Misuse potential is clinically relevant
Class at a glance
- Produce dissociation via NMDA blockade
Practical pearls
- Ketamine is the clinical prototype
Members / distinctions
- Analgesic/anesthetic effects at higher exposure
- Rapid antidepressant effect at subanesthetic dose
Other practical pearls
- BP, perceptual + cognitive effects are common
- Misuse potential is clinically relevant
Drugs in this class (7)
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