Antivirals (HIV NNRTIs)
- Allosterically inhibit HIV reverse transcriptase
- Oral ART anchors with variable resistance barrier
- Doravirine has a relatively clean profile
- Efavirenz: CNS effects + many interactions
- Rilpivirine requires food + gastric acidity
- CYP interactions are common
- Less favored than INSTIs for initial ART
Class at a glance
- Allosterically inhibit HIV reverse transcriptase
Members / distinctions
- Efavirenz: CNS effects + many interactions
- Less favored than INSTIs for initial ART
Pharmacology
- CYP interactions are common
Other member distinctions
- Oral ART anchors with variable resistance barrier
- Doravirine has a relatively clean profile
- Rilpivirine requires food + gastric acidity
Self-check
- How does Antivirals (HIV NNRTIs) work?
Allosterically inhibit HIV reverse transcriptase. - What does rilpivirine require for absorption?
Food and gastric acidity.
Drugs in this class (5)
Antivirals (HIV NNRTIs) prescription history
Animated chart of estimated U.S. prescriptions per year, HIV antiretrovirals (1987–2026). NNRTIs highlighted from 1996.
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