Antivirals (HIV NNRTIs)
- Allosterically inhibit HIV reverse transcriptase
- Oral ART anchors with variable resistance barrier
- Doravirine has a relatively clean profile
- Efavirenz: CNS effects + many interactions
- Rilpivirine requires food + gastric acidity
- CYP interactions are common
- Less favored than INSTIs for initial ART
Class at a glance
- Allosterically inhibit HIV reverse transcriptase
Members / distinctions
- Efavirenz: CNS effects + many interactions
- Less favored than INSTIs for initial ART
Pharmacology
- CYP interactions are common
Other member distinctions
- Oral ART anchors with variable resistance barrier
- Doravirine has a relatively clean profile
- Rilpivirine requires food + gastric acidity
Self-check
- What is the main pharmacologic action of Antivirals (HIV NNRTIs)?
Allosterically inhibit HIV reverse transcriptase.
- What clinically distinguishes Doravirine within Antivirals (HIV NNRTIs)?
a relatively clean profile.
Drugs in this class (5)
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