Antipsychotics (second-generation / SGAs)
- Mainstay antipsychotics; profiles vary widely
- Schizophrenia + bipolar; some adjunct MDD
- clozapine: TRS + suicide-risk reduction
- aripiprazole-like: less prolactin burden
- Metabolic, EPS + prolactin risks vary
- LAIs help when preferred/adherence is poor
- Do not treat “SGA” as one AE profile
Class at a glance
- Mainstay antipsychotics; profiles vary widely
Safety / monitoring
- Schizophrenia + bipolar; some adjunct MDD
- clozapine: TRS + suicide-risk reduction
- aripiprazole-like: less prolactin burden
Clinical role
- LAIs help when preferred/adherence is poor
- Do not treat “SGA” as one AE profile
Safety distinctions
- Metabolic, EPS + prolactin risks vary
Self-check
- Which SGA has a role in TRS and suicide-risk reduction?
Clozapine. - When can LAI antipsychotics help?
When preferred or adherence is poor.
Drugs in this class (15)
Antipsychotics (second-generation / SGAs) prescription history
Animated chart of estimated U.S. prescriptions per year, Antipsychotics (1954–2026).
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