Antipsychotics (first-generation / FGAs)
- Potent D2-blocking antipsychotics
- Schizophrenia; agitation; some antiemetic use
- High-potency → more EPS/prolactin
- haloperidol, fluphenazine
- Low-potency → sedation/orthostasis
- chlorpromazine
- TD/NMS risk; often less metabolic burden
Class at a glance
- Potent D2-blocking antipsychotics
Practical pearls
- High-potency → more EPS/prolactin
- haloperidol, fluphenazine
Clinical role
- Schizophrenia; agitation; some antiemetic use
Safety / monitoring
- Low-potency → sedation/orthostasis
- chlorpromazine
- TD/NMS risk; often less metabolic burden
Self-check
- What adverse-effect burden is greater with high-potency FGAs?
EPS/prolactin. - What adverse effects characterize low-potency FGAs?
Sedation and orthostasis.
Drugs in this class (14)
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