Antipsychotics (dopamine partial agonists)
- D2/D3 partial-agonist antipsychotics
- Schizophrenia; bipolar; adjunct MDD varies
- aripiprazole/brexpiprazole/cariprazine
- Usually low prolactin + lower metabolic burden
- Akathisia is the signature liability
- Cariprazine has long-lived active metabolites
- Aripiprazole has multiple LAI formulations
Class at a glance
- D2/D3 partial-agonist antipsychotics
Practical pearls
- Akathisia is the signature liability
Members / distinctions
- Schizophrenia; bipolar; adjunct MDD varies
- aripiprazole/brexpiprazole/cariprazine
- Usually low prolactin + lower metabolic burden
Other member distinctions
- Cariprazine has long-lived active metabolites
- Aripiprazole has multiple LAI formulations
Self-check
- What distinguishes Cariprazine?
Long-lived active metabolites. - What distinguishes Aripiprazole?
Multiple LAI formulations.
Drugs in this class (6)
Antipsychotics (dopamine partial agonists) prescription history
Animated chart of estimated U.S. prescriptions per year, Antipsychotics (1954–2026). D2 Partial Agonist highlighted from 2002.
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