Antipsychotics (dopamine partial agonists)
- D2/D3 partial-agonist antipsychotics
- Schizophrenia; bipolar; adjunct MDD varies
- aripiprazole/brexpiprazole/cariprazine
- Usually low prolactin + lower metabolic burden
- Akathisia is the signature liability
- Cariprazine has long-lived active metabolites
- Aripiprazole has multiple LAI formulations
Class at a glance
- D2/D3 partial-agonist antipsychotics
Practical pearls
- Akathisia is the signature liability
Members / distinctions
- Schizophrenia; bipolar; adjunct MDD varies
- aripiprazole/brexpiprazole/cariprazine
- Usually low prolactin + lower metabolic burden
Other member distinctions
- Cariprazine has long-lived active metabolites
- Aripiprazole has multiple LAI formulations
Self-check
- What clinically distinguishes Cariprazine within Antipsychotics (dopamine partial agonists)?
long-lived active metabolites.
- What clinically distinguishes Aripiprazole within Antipsychotics (dopamine partial agonists)?
multiple LAI formulations.
Drugs in this class (6)
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