Antifungals (azoles)
- Inhibit fungal ergosterol synthesis
- Fluconazole: Candida; excellent oral bioavailability
- Voriconazole: invasive Aspergillus standard
- Posaconazole/isavuconazole: broader mold activity
- Major CYP interaction burden varies widely
- Hepatotoxicity is a class concern
- QT: most prolong; isavuconazole shortens
Class at a glance
- Inhibit fungal ergosterol synthesis
Safety / monitoring
- Fluconazole: Candida; excellent oral bioavailability
- Voriconazole: invasive Aspergillus standard
- Major CYP interaction burden varies widely
- QT: most prolong; isavuconazole shortens
Members / distinctions
- Posaconazole/isavuconazole: broader mold activity
Safety distinctions
- Hepatotoxicity is a class concern
Self-check
- What is the main pharmacologic action of Antifungals (azoles)?
Inhibit fungal ergosterol synthesis.
Drugs in this class (8)
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