Antifungals (azoles)
- Inhibit fungal ergosterol synthesis
- Fluconazole: Candida; excellent oral bioavailability
- Voriconazole: invasive Aspergillus standard
- Posaconazole/isavuconazole: broader mold activity
- Major CYP interaction burden varies widely
- Hepatotoxicity is a class concern
- QT: most prolong; isavuconazole shortens
Class at a glance
- Inhibit fungal ergosterol synthesis
Safety / monitoring
- Fluconazole: Candida; excellent oral bioavailability
- Voriconazole: invasive Aspergillus standard
- Major CYP interaction burden varies widely
- QT: most prolong; isavuconazole shortens
Members / distinctions
- Posaconazole/isavuconazole: broader mold activity
Safety distinctions
- Hepatotoxicity is a class concern
Self-check
- How does Antifungals (azoles) work?
Inhibit fungal ergosterol synthesis. - Which azole shortens rather than prolongs QT?
Isavuconazole.
Drugs in this class (8)
Antifungals (azoles) prescription history
Animated chart of estimated U.S. prescriptions per year, Antifungals (1947–2026).
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